Exploring the ways in which transatlantic relationships functioned in the nineteenth century to unsettle hierarchical models of gender, race, and national and cultural differences, this collection demonstrates the generative potential of transatlantic studies to loosen demographic frames and challenge conveniently linear histories. The contributors take up a rich and varied range of topics, including Charlotte Smith’s novelistic treatment of the American Revolution, The Old Manor House; Anna Jameson’s counter-discursive constructions of gender in a travelogue; Felicia Hemans, Herman Melville, and the ‘Queer Atlantic’; representations of indigenous religion and shamanism in British Romantic literary discourse; the mid-nineteenth-century transatlantic abolitionist movement; the transatlantic adventure novel; the exchanges of transatlantic print culture facilitated by the Minerva Press; British and Anglo-American representations of Niagara Falls; and Charles Brockden Brown’s intervention in the literature of exploration. Taken together, the essays underscore the strategic power of the concept of the transatlantic to enable new perspectives on the politics of gender, race, and cultural difference as manifested in late eighteenth- and nineteenth-century Britain and North America.